“Let go my LEPTIN” – (science of Obesity)

 

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Leptin

Leptin (Greek leptos meaning thin) is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.  Human leptin is directly proportional to the total amount of fat in the body.

The absence of a leptin (or its receptor) leads to uncontrolled food intake and resulting obesity. Several studies have shown that fasting or following a very-low-calorie diet(VLCD) lowers leptin levels.[8] It might be that on short-term leptin is an indicator of energy balance. This system is more sensitive to starvation than to overfeeding.[9] That is, leptin levels do not rise extensively after overfeeding. It might be that the dynamics of leptin due to an acute change in energy balance are related to appetite and eventually to food intake. Although this is a new hypothesis, there are already some data that support it.

Leptin resistance and obesity

Although leptin is a circulating signal that reduces appetite, in general, obese people have an unusually high circulating concentration of leptin.[31] These people are said to be resistant to the effects of leptin, in much the same way that people with type 2 diabetes are resistant to the effects of insulin. The high sustained concentrations of leptin from the enlarged adipose stores result in leptin desensitization. The pathway of leptin control in obese people might be flawed at some point so the body doesn’t adequately receive the satiety feeling subsequent to eating.

This is all new research on how the body has two “brains” one in your head and one in the gut.  Our bodies may be driven by both brains.

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About David Nuckols

Inspiring individuals to learn about the human body to motivate lifestyle changes that improve their own self-image

Posted on October 7, 2010, in Home and tagged , , , , , , , , , , , , , , , , . Bookmark the permalink. Leave a comment.

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